Scientists have been uncertain as to how the bacterium which is responsible for spreading cholera was able to oppose the fundamental inborn immune reaction. The mystery which existed for five decades has at last been resolved; credit goes to the biologists belonging to the Univesty of Texas, Austin. They conducted a research and solved the mystery.

The outcomes of the research can assist in clearing the way of a new type of antibiotics that don’t unswervingly close down the pathogenic bacteria like V. cholera, however as an alternative immobilize their resistances; hence our individual impervious systems can do the carnage.

Annually cholera troubles people in millions and destroys hundreds of thousand mainly in the urbanized globe. The infection creates vomiting and abundant diarrhea. Acute dehydration causes death.

An associate professor of microbiology &molecular genetics and lead investigator, said if one identifies the mechanism of bacterial target, he then will be able to plan an efficient antibiotic.

The defense of bacterium which was exposed in the monthly “Proceedings of the National Academy of Sciences”, comprise connecting 1 or 2 tiny amino acids to the big molecules called as endotoxins, which encompasses nearly 75% of the external surface of the bacterium.

The professor said the small aminoacids easily alters the electric charge on the bacteria’s external surface .It shifts from pessimistic to unbiased.

That’s vital since the molecule we depend on combat such kind of germs that are known as CAMPs (cationic antimicrobial peptides) are charged optimistically. They will be able to connect to the bacteria’s pessimistically charged façade and whilst they do so they put in themselves into the membrane of the bacteria and create an aperture. Water then runs through this hole into the bacterium and from inside explodes it open destroying the detrimental bacteria.

For some time the scientist learnt the fact V.Cholerae’s strain, accountable for the present deadly disease in Haiti and other place is opposing to these CAMPs. It is the opposition, which is probably responsible for these pandemics.

Now researchers have understood the mechanism behind the opposition. They expect to utilize the information to develop the antibiotics, which can immobilize the resistance, maybe by prohibiting the cholera bacteria from solidifying their shield. If this becomes feasible, then the CAMPs are capable of doing rest of the things.

The antibiotics has considerable advantages .It is efficient in combating and preventing not only cholera but also other hazardous diseases that utilize the same resistance.